Scientist Quotes

In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize.
Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease.
No one ever said, 'Be a doctor.' But because so many members of my extended family - aunts, uncles - were doctors, there was this expectation that I'd probably be a physician.
Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening.
One characteristic aspect of ageing is the increased susceptibility to disease, particularly age-related diseases such as cardiovascular diseases and cancer.
Perhaps arising from a fascination with animals, biology seemed the most interesting of sciences to me as a child.
Researchers have found that the brain definitely sends nerves directly to organs of the immune system and not just to the heart and the lower gut. In that way, too, the brain is influencing the body.
Studying organisms at a molecular level was totally compelling because it was moving from being a naturalist, which was the 19th-century kind of science, to being very focused and really getting to the heart of these molecules.
Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.
The conservative statement is that telomere length is a biomarker, but it's probably not passive. There are some very intimate relationships between things such as molecular markers for inflammation and telomere health.
The goal is to learn more about telomere length and other markers of ageing, how best to measure these markers, how they are related to health and lifestyle, and how people respond to learning their own telomere length results.
The most dangerous cancer cells are actually the ones that are more like stem cells, which have this ability to produce themselves over and over again. More and more cancer biologists say stem-cell-like cells in cancers are the most dangerous.
This enzyme, called telomerase, slows the rate at which telomeres degrade, and research indicates that healthy people with longer telomeres have less risk of developing the common illnesses of aging - like heart disease, diabetes, and cancer, which are three big killers today.
Tracing the beginnings of the interwoven stories of science can be arbitrary, as beginnings are so often lost in the mists of time.
We and other groups are seeing clear statistical links between telomere shortness and risk for a variety of diseases that are becoming very common, such as cardiovascular disease, diabetes and certain cancers.
We think there are lifestyle factors that boost telomerase naturally.
We're collecting about 100,000 telomere lengths in saliva samples and then looking at how those relate to both the extensive longitudinal clinical records that Kaiser is collecting and the genome sequence variations.
We're involved in a very large study that's federally funded and being done with Kaiser Permanente, and saliva is a very non-invasive way to get cells from the body.
What is it that keeps you so interested in the telomere? It's so intricate and complicated, and you want to know how it works.
When scientists get old, they get interested in the brain, and I'm a little bit afraid I'm falling into that.
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