Charles Jules Henry Nicole Quotes

At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used.

~ Charles Jules Henry Nicole

Conducting Guinea Known Method Now Pig Research Taking Technique Temperature Time Used Which Widely

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Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated.

~ Charles Jules Henry Nicole

Animals Been Consequently Demonstrate Disease Even Had Hypothesis Observation Possible Reproduce Simple Sufficient Verify Way Which Would

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From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus.

~ Charles Jules Henry Nicole

Animal Forward Guinea Guinea Pig Infection Most Pig Point Practical Preserving Proved Step Step Forward Today Use Useful View Virus

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I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced.

~ Charles Jules Henry Nicole

After Appears Characteristics Days Duration Experimental Fever Five Follows Less Man Natural Never Pattern Period Same Than Which

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I finally demonstrated that typhus infection is not hereditary in the louse.

~ Charles Jules Henry Nicole

Finally Hereditary Infection Typhus

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I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals.

~ Charles Jules Henry Nicole

Against Animals Attempts Effect Large Less Preventive Produce Quantities Successful Trying Typhus Using Vaccination Virus

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It did not seem likely that I was destined to undertake research on typhus.

~ Charles Jules Henry Nicole

Destined Did Likely Research Seem Typhus Undertake

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Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection.

~ Charles Jules Henry Nicole

After Becomes Bite Day Following Immediately Infection Just Man Meal Nature Only Provided Reservoir Towards Typhus Virus

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Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it.

~ Charles Jules Henry Nicole

Administration Approximately Country Died Districts Doctors Most One-Third Them Third Those Typhus

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My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today.

~ Charles Jules Henry Nicole

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Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread.

~ Charles Jules Henry Nicole

Contagion Knew Me Most Nothing Open Problems Spread Study Typhus Unexplored Urgent Way Were Which

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The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal.

~ Charles Jules Henry Nicole

Also Animal Discovery Guinea Guinea Pig Infection Made Me Pig Possible Preserve Soon Susceptible Third Virus Year

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The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread.

~ Charles Jules Henry Nicole

Because Contacts Contagion Daily Disease Enough Escape Fact Fortunate Frequent How Sometimes Soon Spite Spread

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